• Bioengineering in action

    Bioengineering in action

How polynerve works

Polynerve works by creating an artificial pathway that guides nerve fibres across the gap between severed nerve endings (caused by an accident) and muscle or skin.

This physical guidance is extremely important to nerve regeneration. To provide it, the Polynerve team has developed novel grooves within the conduit’s inner lumen. These align Schwann cells (the supportive cell of the peripheral nerve) and direct them across the gap, maximising the regeneration potential.

THE NEED FOR AN ALTERNATIVE APPROACH

Read Dr Adam Reid on current clinical shortcomings

Bioengineered grooves for Schwann cell alignment and direction

  • The Polynerve conduit

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    Grooves

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    Schwann cells

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    Without grooves

    With non-grooved polymer, Schwann cells have no alignment or direction, which reduces the potential for regeneration.

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    With grooves

    With Polynerve grooved conduits, Schwann cells are aligned and directed, leading to improved repair of severed nerves.