POTENTIAL FOR REGENERATIVE MEDICINE
Polynerve has great potential in regenerative medicine because its design will facilitate delivery of cell therapy for nerve repair. Indeed, our aim is to combine the regenerative potential of adult stem cells with the physical guidance provided by the internal microstructure and topography of Polynerve to achieve better regeneration outcomes following nerve injury.
Schwann Cells, the regenerative cells of the peripheral nervous system, cannot be used for this purpose due to difficulties in sourcing the donor tissue and expansion to a sufficient number. Our team is investigating methods to obtain Schwann cell substitutes by using adult stem cells obtained from human fat. Indeed, fat is one of the most promising and abundant sources of stem cells with low donor morbidity issues, fewer ethical implications and great promise for regenerative medicine applications.
We are currently studying the close interactions between these adipose-derived Schwann cell substitutes and Polynerve to optimise stem cell delivery. We are working towards future clinical trials with patients who have suffered a peripheral nerve injury.
Stem cells from human fat. These can be harnessed to improve nerve regeneration.